Transcranial sonography in clinical practice: new potential of using the method in patients with Parkinson’s disease

К.V. Mazurenka

Abstract


Background. Transcranial sonography is an ultrasound method used for early diagnosis of Parkinson’s disease (PD). The purpose of the study was to establish potential of the transcranial sonography for detecting PD clinical symptoms, to develop neuroimaging biomarkers of cerebral atrophy, accompanied by cognitive impairment in patients with PD. Materials and methods. The study involved 100 patients with PD and 31 healthy controls matched for age, sex and education. We assessed the cognitive impairment severity and parameters of transcranial sonography (hyperechogenicity area of substantia nigra, the width of the III ventricle, the width of the frontal horns of the lateral ventricle). Results. We have found an inverse correlation between the total area of substantia nigra hyperechogenicity, as well as the width of III ventricle and the results of neuropsychological testing of patients with PD (p < 0.001). Using ROC-analysis we calculated optimal threshold division of the III ventricle width that allows evaluate atrophic changes in the brain, accompanied by cognitive decline in patients with PD, which was 7.4 mm, AUC 0.78 (95% CI 0.68–0.89). P value equal to 0,  showed a good informative value of the identified neuroimaging criteria. Transcranial sonography had sensitivity 82.1 %, specificity 77.8 %, diagnostic accuracy 81.2 % for the evaluation of cerebral atrophy, accompanied by cognitive impairment in patients with PD.

Keywords


Parkinson’s disease; transcranial sonography; substantia nigra hyperechogenicity; third ventricle; cognitive impairment

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DOI: https://doi.org/10.22141/2224-0713.3.89.2017.104255

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