Modern aspects of the diagnosis and treatment for chronic traumatic encephalopathy (literature review)

V.O. Malakhov, V.S. Lychko


Physical culture and sport have a positive effect on the human body, although certain sports can cause injury. Boxing is a sport with a high risk of brain injury, as well as the long-term consequences of training injuries sustained during boxing. In boxing, there is a direct threat to the opponent’s head, as often the victory is awarded when the opponent loses consciousness. Chronic traumatic encephalopathy is an extremely urgent medical and social problem, not only in Ukraine, but all over the world. The article deals with the increasing knowledge about the negative effects of frequent traumatic brain injuries when practicing power sports, which are then transformed in Martland’s syndrome. At present, both domestic and foreign literature data on this pathology are quite incomplete. The article will be useful for medical students, interns and various specialists — neurologists, neurosurgeons, family physicians, internists, psychiatrists, neuroscientists, recreation therapists, experts in occupational pathologies. Such injuries can cause irreparable harm to the intracranial structures, and the consequences of power sports can be quite unpredictable — from acute complications by concussion type to chronic processes leading to dementia in athletes. Statistics on development of the disease in athletes were analyzed. In the world medical and sports circles, the safety of sports, the prevention of injuries, especially brain injuries, and the verification of early signs of brain trauma are seriously debated. The article describes the main pathogenic, clinical and therapeutic aspects of the disorders of the functioning of the central nervous system in this nosology. Special attention is paid to the problem of the treatment of chronic traumatic encephalopathy.


traumatic brain injury; axonal injury; dementia; encephalopathy; boxer


Martland H.S. Punch drunk // JAMA. — 1928. — 19. — 1103-1107.

Baugh C.M., Stamm J.M., Riley D.O., Gavett B.E., Shenton M.E., Lin A. Chronic traumatic encephalopathy: neurodegeneration following repetitive concussive and subconcussive brain trauma // Brain Imaging Behav. — 2012. — 2. — 244-54.

Ryan A.J. Intracranial injuries resulting fromboxing // Clin. Sports. Med. — 1998. — Vol. 17. — P.155-168.

Baugh C.M., Robbins C.A., Stern R.A., McKee A.C. Current Understanding of Chronic Traumatic Encephalopathy // Curr. Treat.Options. Neurol. — 2014. — 16. — 306.

Amadoro G., Ciotti M.T., Costanzi M., Cestari V., Calissano P.,

Canu N. NMDA receptor mediates tau-induced neurotoxicity by calpain and ERK/MAPK activation // Proc. Natl Acad. Sci. USA. — 2006. — 103. — 2892-7.

Unterharnscheidt F., Tailor-Unterharnscheidt J. Boxing medical aspects. — Elsevier Science Ltd, 2003. — 796 p.

Arriagada P.V., Growdon J.H., Hedley-Whyte E.T., Hyman B.T. Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer’s disease // Neurology. — 1992. — 42. — 631-9.

Omalu B.I., Bailes J., Hammers J.L., Fitzsimmons R.P. Chronic traumatic encephalopathy, suicides and parasuicides in professional American athletes: the role of the forensic pathologist // Am. J. Forensic Med. Pathol. — 2010. — 31. — 130-2.

Warden D.L., Bleiberg J., Cameron K.L. et al. Persistent prolongation of simple reaction time insports concussion // Neurology. — 2001. — Vol. 57. — P. 524-526.

Mez J., Stern R.A., McKee A.C. Chronic Traumatic Encephalopathy: Where Are We and Where Are We Going? // Curr. Neurol. Neurosci. Rep. — 2013. — 13. — 407.

McKee A.C., Stein T.D. The spectrum of disease in chronic traumatic encephalopathy // Brain. — 2012. — 1-22. doi:10.1093/brain/aws307.

Pineda P., Gould D.J. The neuroanatomical relationship of Dementia Pugilistica and Alzheimer’s Disease // Neuroanatomy. —2010. — 9. — 5-7.

Zazryn T.R., McCrory P.R., Cameron P.A. Neurologic injuries in boxing and other combat sports // Neurol. Clin. — 2008. — Vol. 26. — P. 257-270.

Kesler S.R. SPECT, MR and quantitative MR imaging: correlates with neuropsychological and psychological outcome in traumatic brain injury // Brain Inj. — 2000. — Vol. 14. — P. 851-857.


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